{"@context":"https://schema.org","@type":"ScholarlyArticle","headline":"A long‐lasting topical deltamethrin treatment to protect dogs against visceral leishmaniasis","author":[{"@type":"Person","name":"Orin Courtenay"},{"@type":"Person","name":"V. Kovačić"},{"@type":"Person","name":"P. A. F. Gomes"},{"@type":"Person","name":"L. Garcez"},{"@type":"Person","name":"R. Quinnell"}],"datePublished":"2009","isPartOf":{"@type":"Periodical","name":"Medical and Veterinary Entomology"},"identifier":"https://doi.org/10.1111/j.1365-2915.2009.00815.x","description":"Abstract.\n \n To develop long‐lasting, topical pour‐on insecticides for dogs to control zoonotic visceral leishmaniasis, two deltamethrin‐based formulations (emulsifiable concentrate [EC] and suspension concentrate [SC]) were tested for their efficacy against the phlebotomine sandfly\n Lutzomyia longipalpis\n Lutz & Neiva (Diptera: Psychodidae), vector of\n Leishmania infantum\n Nicolle (Kinetoplastida: Trypanosomatidae). The entomological outcomes tested were anti‐feeding effect (proportion of female sandflies unfed), lethal effect (24‐h female sandfly mortality) and these two effects combined, and the insecticide persistence time at 50% (residual activity, RA\n 50\n ) and 80% (RA\n 80\n ) efficacy. On initial application, the proportions of female flies that demonstrated anti‐feeding activity or were killed were similar for both formulations, at 0.93 (95% confidence interval [CI] 0.856–0.977) vs. 0.81 (95% CI 0.763–0.858) (anti‐feeding) and 0.86 (95% CI 0.787–0.920) vs. 0.76 (95% CI 0.698–0.817) (24‐h mortality) for EC and SC, respectively. The RA\n 50\n rates for anti‐feeding and mortality caused by the EC formulation were 4.7 months (95% CI 4.18–5.84) and 2.5 months (95% CI 2.25–2.90), respectively, compared with 1.1 months (95% CI 0.96–1.15) and 0.6 months (95% CI 0.50–0.61), respectively, for the SC formulation. The RA\n 50\n for the combined anti‐feeding and mortality effects of EC was 5.2 months (95% CI 4.73–5.96), compared with only 0.9 months (95% CI 0.85–1.00) for the SC formulation. The four‐ to six‐fold superior residual activity of the EC formulation was attributed to the addition of a solvent‐soluble resin in the formulation which improved fur adhesion and acted as a reservoir for the slow release of the active ingredient. These results identify the potential of such a low‐cost formulation to reduce the inter‐intervention interval to 5–6 months, similar to that recommended for deltamethrin‐impregnated dog collars or for re‐impregnation of conventional bednets, both of which are currently used to combat\n Leishmania\n transmission. Finally, a novel bioassay was developed in which sandflies were exposed to fur from treated dogs, revealing no detectable tolerance (24‐h mortality) in wild‐caught sandflies to the insecticide formulations up to 8 months after the initiation of communitywide application of the insecticides to dogs.\n ","url":"https://innscience.ca/en/community/literature/f1b7319e-7f29-45ca-9b26-fa3be7699768"}