{"@context":"https://schema.org","@type":"ScholarlyArticle","headline":"EHealth intervention for quality of life in long-term breast cancer survivors: Randomized controlled trial.","author":[{"@type":"Person","name":"Gustavo Adolfo Pimentel-Parra"},{"@type":"Person","name":"Nelia Soto-Ruiz"},{"@type":"Person","name":"Paula Escalada-Hernández"},{"@type":"Person","name":"Leticia San Martín-Rodríguez"},{"@type":"Person","name":"Cristina García-Vivar"}],"datePublished":"2026","isPartOf":{"@type":"Periodical","name":"Journal of the National Cancer Institute"},"identifier":"https://doi.org/10.1093/jnci/djag020","description":"Abstract\n \n Background\n Digital health interventions have shown promise for improving quality of life, especially in the short term after treatment. However, evidence regarding long-term breast cancer survivors (LT-BCSs; disease free >5 years) remains limited. This study aimed to evaluate the effectiveness of an eHealth intervention targeting health promotion and late sequelae management to improve LT-BCSs’ quality of life.\n \n \n Methods\n In a randomized controlled clinical trial, 201 LT-BCSs (mean = 11 years posttreatment) were randomly assigned to an intervention group (n = 102) using the CUMACA-M mobile application with specific health advice and recommendations for LT-BCSs, or a control group (n = 99) receiving usual care. Quality of life was measured with the Quality of Life–Cancer Survivors (QOL-CS) scale at baseline and after 3 months. Analyses followed an intention-to-treat approach using t tests, nonparametric tests, and effect sizes.\n \n \n Results\n At 3 months, no statistically or clinically significant differences between the groups in the overall quality of life score (QOL-CS) were found (difference-in-differences = 0.11; 95% confidence interval = −0.10 to 0.32; P = .303). In the intervention group, a small intragroup decrease in spiritual well-being was observed (−0.25; −0.49 to −0.02), of uncertain clinical significance; no significant differences between groups were detected.\n \n \n Conclusions\n This eHealth intervention did not improve the quality of life of LT-BCSs, suggesting that more personalized, interactive, or professionally supported strategies may be needed. Future research should evaluate the long-term outcomes and effectiveness of hybrid or personalized digital strategies in this population.\n \n \n Trial Registration\n ClinicalTrials.gov NCT05322460; https://clinicaltrials.gov/study/NCT05322460.\n ","url":"https://innscience.ca/en/community/literature/doi_10_1093_jnci_djag020"}