{"@context":"https://schema.org","@type":"ScholarlyArticle","headline":"Association between hysterectomy for benign indications and the risk of breast cancer: a systematic review and meta- analysis.","author":[{"@type":"Person","name":"Wenjing Liu"},{"@type":"Person","name":"Tingting Lu"},{"@type":"Person","name":"Jingqi Yang"},{"@type":"Person","name":"Jie Liu"}],"datePublished":"2025","isPartOf":{"@type":"Periodical","name":"Frontiers in oncology"},"identifier":"https://doi.org/10.3389/fonc.2025.1600459","description":"\n Objectives\n To determine the association between hysterectomy performed for benign indications and the risk of developing BC.\n \n \n Methods\n \n A literature search was conducted in PubMed, Embase, and the Cochrane Library from database inception up to December 11, 2024. Eligible studies were observational design. Relative ratios (RRs) and 95% confidence intervals (CIs) were pooled using a random-effects model,\n \n I\n 2\n \n was used to assess the heterogeneity between studies.\n \n \n \n Results\n \n This meta-analysis included 12 studies, consisting of 4 case-control studies and 8 cohort studies. The pooled analysis of case-control studies indicated that hysterectomy reduced the risk of BC (RR = 0.839, 95% CI: 0.707-0.995,\n P\n = 0.043,\n \n I\n 2\n \n = 81.661%). However, the pooled analysis of cohort studies did not observe a significant association between hysterectomy and the occurrence of BC (RR = 0.981, 95% CI: 0.927-1.037,\n P\n = 0.495,\n \n I\n 2\n \n = 60.319%).\n \n \n \n Conclusions\n The present study reveals a protective effect of hysterectomy on the occurrence of BC in case-control studies. However, more studies, especially cohort studies, are needed to elucidate the potential beneficial effects of hysterectomy on the development of BC.\n \n \n Systematic Review Registration\n \n https://www.crd.york.ac.uk/PROSPERO/view/CRD42024596235\n , identifier CRD42024612164.\n \n ","url":"https://innscience.ca/en/community/literature/be992763-7624-4d95-995a-b9339e7e775f"}