{"@context":"https://schema.org","@type":"ScholarlyArticle","headline":"A local human Vδ1 T cell population is associated with survival in nonsmall-cell lung cancer.","author":[{"@type":"Person","name":"Yin Wu"},{"@type":"Person","name":"Dhruva Biswas"},{"@type":"Person","name":"Ieva Usaite"},{"@type":"Person","name":"Mihaela Angelova"},{"@type":"Person","name":"Stefan Boeing"},{"@type":"Person","name":"Takahiro Karasaki"},{"@type":"Person","name":"Selvaraju Veeriah"},{"@type":"Person","name":"Justyna Czyzewska-Khan"},{"@type":"Person","name":"Cienne Morton"},{"@type":"Person","name":"Magdalene Joseph"},{"@type":"Person","name":"Sonya Hessey"},{"@type":"Person","name":"James Reading"},{"@type":"Person","name":"Andrew Georgiou"},{"@type":"Person","name":"Maise Al-Bakir"},{"@type":"Person","name":"Nicholas McGranahan"},{"@type":"Person","name":"Mariam Jamal-Hanjani"},{"@type":"Person","name":"Allan Hackshaw"},{"@type":"Person","name":"Sergio A Quezada"},{"@type":"Person","name":"Adrian C Hayday"},{"@type":"Person","name":"Charles Swanton"}],"datePublished":"2022","isPartOf":{"@type":"Periodical","name":"Nature cancer"},"identifier":"https://doi.org/10.1038/s43018-022-00376-z","description":"AbstractMurine tissues harbor signature γδ T cell compartments with profound yet differential impacts on carcinogenesis. Conversely, human tissue-resident γδ cells are less well defined. In the present study, we show that human lung tissues harbor a resident Vδ1 γδ T cell population. Moreover, we demonstrate that Vδ1 T cells with resident memory and effector memory phenotypes were enriched in lung tumors compared with nontumor lung tissues. Intratumoral Vδ1 T cells possessed stem-like features and were skewed toward cytolysis and helper T cell type 1 function, akin to intratumoral natural killer and CD8+ T cells considered beneficial to the patient. Indeed, ongoing remission post-surgery was significantly associated with the numbers of CD45RA−CD27− effector memory Vδ1 T cells in tumors and, most strikingly, with the numbers of CD103+ tissue-resident Vδ1 T cells in nonmalignant lung tissues. Our findings offer basic insights into human body surface immunology that collectively support integrating Vδ1 T cell biology into immunotherapeutic strategies for nonsmall cell lung cancer.","url":"https://innscience.ca/en/community/literature/a0feb76a-2a60-4f50-a14b-8179f043d06f"}